The Frenetic Quest for Relevance

the quest for an hiv vaccine

TET proteins: on the frenetic hunt for new cytosine modifications

Epigenetic genome marking and chromatin regulation are central to establishing tissue-specific gene expression programs, and hence to several biological processes. Until recently, the only known epigenetic mark on DNA in mammals was 5-methylcytosine, established and propagated by DNA methyltransferases and generally associated with gene repression. All of a sudden, a host of new actors-novel cy...

The frenetic origin of negative differential response

The Green-Kubo formula for linear response coefficients gets modified when dealing with nonequilibrium dynamics. In particular negative differential conductivities are allowed to exist away from equilibrium. We give a unifying framework for such negative differential response in terms of the frenetic contribution in the nonequilibrium formula. It corresponds to a negative dependence of the esca...

Business Technology Education in the Early 21st Century: The Ongoing Quest for Relevance

The field of information technology is changing and those responsible for educating the next generation of technology professionals have responded with a new computing curriculum, which identifies five distinct technology majors: computer engineering, computer science, software engineering, information systems and information technology. Unfortunately, the new curricula fail to address the dept...

The Slippery Slope of MIS Academia: A Discussion of the Quest for Relevance in Our Discipline

The MIS discipline faces the need to periodically re-establish its relevance to both academics and practitioners. Evolving technology forces our discipline to change at a rate far exceeding that of other business disciplines. In the workplace, rapidly evolving IT management issues and technologies have led corporations to manage technical employees differently than other employees. In academia,...